brand of vitamin K-1(phytonadione);
the natural plant vitamin K that is free
of the toxicity associated with syn-
thetic menadione.
An ever-increasing list of drugs and
supplements is being shown to lower
vitamin K dependent protein levels.
analgesics
antibiotics
anticoagulants
anticonvulsants
Vitamin E etc. etc.
This figure illustrates the importance
of vitamin K-1 in post-translational
modification of certain glutamic acid
residues into gamma-carboxy g.acid.
The presence of gamm-carboxy res-
idues allows that protein to specific-
ally bind calcium ions more avidly.
CLOTTING FACTORS
II (Prothrombin)
VII, IX and X
Vitamin K enables these
proteins to bind to calcium
ions and platelet derived
phospholipids in the clot-
ting process.
PROTEINS S and C
Like the classic clotting
factors, these VKDP are
formed in the liver and
then circulate to promote
fibrinolysis and anti-
coagulation!
